Article Abstract:
Glucose repression by URS (sub G) was investigated through identification of a number of mutants that lacked URS (sub G)-mediated repression. Trans-acting factors of the glucose repression pathway was found to be important for the repression activity of the cis-acting promoter elements. URS (sub G)-mediated glucose repression was not affected by orientation or location within a promoter that indicates the presence of binding sites for glucose-activated repressor proteins. Three new genes needed for the URS (sub G) glucose repression were discovered and were found to encode the repressor proteins.
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Article Abstract:
A study was conducted to analyze HTS1 encoding of mitochondrial and cytoplasmic histidyl-tRNA synthetases (Hts). Genetic and biochemical experiments indicate a single HTS1 gene is needed for such encoding process. Results show that the gene posseses an amino-terminal presequence in the mitochondrial precursor and a supporting amino-terminal sequence in both precursor and cytoplasmic form. The Hts protein's compartmentation specificity is conditioned by primary sequence and protein concentration.
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Article Abstract:
New extragenic suppressors of mutations in the SPT3, SPT7, SPT8 and SPT15 gene called rsp, for reverses Spt negative phenotype, were isolated and analyzed. The new mutations alters the expression of delta insertions in spt positive strains. RSP genes so far identified numbers four. They encode frameshift mutations in glycine transfer RNA suppressor. Other genetic properties of the new mutations are discussed.
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