An initial blueprint for myogenic differentiation

Article Abstract:

Genome-wide transcription factor binding and expression profiling were combined in order to assemble a regulatory network controlling the myogenic regulatory factors (MRFs)-MyoD and myogenin-and Myocyte Enhancer Factor 2 (MEF2). The studies highlight unanticipated biological insights related to muscle development and focus on new directions for studies on genes associated with muscle repair and response to stress and damage.

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Switching of the core transcription machinery during myogenesis

Article Abstract:

The fate of the core promoter recognition complex, TFIID during skeletal myogenesis is assessed. The switching of core promoters are observed that provides organism a simple yet effective means of selectively turns on one transcriptional program while silencing many others.

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The Notch coactivator, MAML1 functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis

Article Abstract:

MAML1 (mastermind-like) acts as a coactivator for MEF2C (myocyte enhancer factor 2C) transcription and is essential for proper muscle development. Mechanistically, MAML1 appears to mediate cross-talk between Notch and MEF2 to influence myogenic differentiation.

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