Article Abstract:
Several studies have been conducted to examine changes in the chromatin structure that involve the disruption or reformation of nucleosomes, termed chromatin remodeling complexes. Some of the studies indicated that at least the ISWI or Swi2 polypeptides comprise the engine of the remodeling machine, since chromatin remodeling activities containing these polypeptides were found to increase the accessibility of nucleosomal DNA to transcription factors or other DNA-binding proteins. However, findings also suggested that there are still several complexes involved and the biological roles of each have yet to be determined.
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Article Abstract:
The function of the erythroid Kruppel-like factor (EKLF) was investigated in relation to stage-specific expression of the human beta-globin gene. EKLF deficiency in transgenic mice resulted to death caused by anemia during the developmental stage. Also, the function of the chromatin remodeling complexes such as the SWI/SNF contributed to the transcription of a tissue-specific regulated gene. Therefore, chromatin remodeling and transcriptional activity depended upon the coactivation of EKLF and the SWI/SNF complex, E-RC1.
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Article Abstract:
NF-kappaB, the prototype of a family of dimeric transcription factors, was discovered in 1986. The family was made from monomers with approximately 300 amino-acid Rel regions which bind to DNA, interact with each other and bind the IkappaB inhibitors. Following the discovery of the prototype, researchers decided to meet regularly to keep updated on developments regarding the family. The first meeting was held in 1992 and the second in 1993. The latest was held in Madrid, Spain, in 1996.
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