An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3

Article Abstract:

Steroid hormones penetrate cells by diffusion through the plasma membrane. However, it was observed that some steroid hormones are taken up by receptor-mediated endocytosis of steroid-carrier complexes. It was also discovered that 25-(OH) vitamin D3 in complex with its plasma carrier, the vitamin D-binding protein, is filtered through the glomerulus and reabsorved in the proximal tubules by the endocytic receptor megalin.

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Role of endocytosis in cellular uptake of sex steroids

Article Abstract:

The possible role of megalin in the cellular delivery of sex steroids and the consequences of receptor deficiency for androgen and estrogen action in vivo are investigated. The findings uncover the existence of endocytic pathways for protein bound androgens and estrogens and their critical role in development of the reproductive organs.

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Response: Cellular uptake of sex steroid hormones

Article Abstract:

The role of megalin, an endocytic receptor of the low-density lipoprotein (LDL) receptor gene family, in reproductive tissues is discussed. Impaired development of male and female reproductive tissues and sex steroid insensitivity is a result of deficiency in the megalin receptor.

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