Article Abstract:
a yeast aminoacylation-dependent nuclear tRNA export pathway is discussed. A suppressor screen of a synthetically lethal los1 mutant has been carried out to find factors than disruption of LOS1 that help in tRNA export. Also the essential translation elongation factor eEF-1A was identified. It was found that tRNA aminoacylation and eEF-1A are needed for efficient nuclear tRNA export in yeast. It appears that coordination of the protein translation and the nuclear tRNA processing and transport mechanisms exists.
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Article Abstract:
Nitric oxide (NO) synthase has been found to be induced in Physarum polycephalum sporulation. P. polycephalum expresses a calcium-independent NO synthase like the inducible NO synthase (NOS) isoenzyme in mammals. It has been cloned and sequnced and is the first nonanimal NOS identified. Less than 39% of its amino acids are identical to those of known NOSs. The second messenger used for NO siglnaling in sporulation is cGMP. It links the signaling pathway to expression of lig1.
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Article Abstract:
The yeast SUB2/yUAP56 gene roles in splicing are discussed in this research communication. The Schizosaccharomyces pombe ortholog of the UAP56 gene by heterologous complementation of a combined PRP40HA(sub.3)/nam 8(Delta) defect in budding yeast has been isolated. It was found that SUB2 participates in splicing in vivo and in vitro. U2snRNP likely has a role in events before prespiceosome formation.
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