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Agents that increase the permeability of the outer membrane

Article Abstract:

Antibacterial agents such as polycations and chelators exhibit permeability across the cell walls of gram-negative bacteria. These two agents disrupts the molecular interactions of the lipopolysaccharide segments of the outer membrane. Polycations attach themselves to anionic regions of these lipopolysaccharides of the membrane and cause the membrane to be susceptible to drug traversion. Some polycations possess other qualities aside from their cationic properties that make them better permeabilizers than others. Chelates destroys the outer membrane in order to cross the cell wall.

Analysis, Physiological aspects, Antibacterial agents, Bacterial cell walls

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The complete general secretory pathway in gram-negative bacteria

Article Abstract:

Protein transport across the cytoplasm of gram-negative bacteria by the general secretory pathway (GSP) requires hydrophobic amino acids. The translocation of hydrophilic polypeptides needs at least six different sec gene-encoded proteins and is dependent on ATP hydrolysis and the electrochemical potential. Other variants of the GSP terminal branch have been identified and presented.

Secretion, Physiological regulation, Biological transport

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Molecular biology of the symbiotic-pathogenic bacteria Xenorhabdus spp. and Photorhabdus spp

Article Abstract:

Molecular genetic studies of the phenotypically similar gram-negative gamma bacteria species Xenorhabdus and Photorhabdus showed differences in bioluminescence and lipase characteristics. Outer membrane protein examinations also led to the assumption that the phenotypic similarities of the two species could be from a horizontal convergence from different gene pools.

Membrane proteins, Molecular biology, Cell membranes, Host-parasite relationships

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