Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels

Article Abstract:

An estimated 1,343 single-nucleotide polymorphisms (SNPs) are genotyped in 1,184 African Americans from the Health, Aging and Body Composition (Health ABC) Study to identify genes influencing the levels of the inflammatory markers. Results reveal a significant association of interleukin 6 soluble receptor (IL-6SR) with European ancestry on chromosome 1 in a region that includes the gene for this receptor (IL-6R).

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Combining evidence of natural selection with association analysis increases power to detect malaria- resistance variants

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The article describes a case 'control association study of malaria resistance. Results demonstrated that combining association analysis with evidence of natural selection could increase power to detect risk variants by order of magnitude.

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Admixture mapping of white cell count: Genetic locus responsible for lower white blood cell count in the health ABC and Jackson Heart Studies

Article Abstract:

A survey was conducted on the entire genome for loci underlying the difference in white blood cell count (WBC) among African Americans using admixture mapping in the Health, Aging and Body Composition and Jackson Heart Studies.

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