Adaptive acid tolerance response in Listeria monocytogenes: isolation of an acid-tolerant mutant which demonstrates increased virulence

Article Abstract:

The adaptive acid tolerance response of Listeria monocytogenes to low-pH environments is studied via laboratory procedures. Results indicate that induction of the acid tolerance response protects L. monocytogenes against environmental stresses, such as osmotic stress and thermal stress. The data also suggest that adaptation in L. monocytogenes requires protein synthesis to offset the effects of chloramphenicol.

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Listeria monocytogenes PerR mutants display a small-colony phenotype, increased sensitivity to hydrogen peroxide, and significantly reduced murine virulence

Article Abstract:

The consequences of the deletion of perR in Listeria monocytogenes for bacterial fitness and the identification of a number of PerR-regulated genes in Listeria are reported. The results have shown that L. monocytogenes PerR mutants are actually less resistant to peroxide stress and that the ability to cause infection in the mouse model is dramatically affected.

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Bile salt hydrolase activity in probiotics

Article Abstract:

The ecological significance of bile salt hydrolase (BSH) production is explored and the impact that bile hydrolysis may have on human physiology is examined. It is shown that bile salt hydrolase (BSH) enzymes might confer a selective advantage on probiotic strains in the highly competitive environment of the human intestinal tract.

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