Acid phosphatase locus 1 (ACP1): possible relationship of allelic variation to body size and human population adaptation to thermal stress - a theoretical perspective

Article Abstract:

Research on alleles polymorphic frequencies at the acid phosphatase locus 1, or ACP1, is presented. Worldwide collected data reveals that there may be a relationship between function of the ACP1 to modulate growth and may be a component in the selective processes influencing human body mass and population adaptations to various thermal stresses, by comparing northern and southern latitudes.

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ACP1 and human adaptability: association with past malarial morbidity in the Sardinian population

Article Abstract:

The association between acid phosphatase locus 1 (ACP1) and past malarial morbidity in Sardinia has been examined, with results indicating that the S isoform plays a role in susceptibility to malaria, which is not mediated by glucose-6-phosphate dehydrogenase (G-6-PD) deficiency. Possible mechanisms for ACP1 involvement in resistance to malaria are discussed.

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Genetics of signal transduction and effect of material smoking in sex ratio of offspring

Article Abstract:

ACP1 is a highly polymorphic enzyme involved in signal transduction of growth factors, glucose metabolism, flavoenzyme activity, and T-cell activation. The possible effects of ACP1 on the relationship between material smoking and sex ratio of offspring are investigated.

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