Acf1 confers unique activities to ACF/CHRAC and promotes the formation rather than disruption of chromatin in vivo

Article Abstract:

The assembly of chromatin is a fundamental biological process that occurs in proliferating cells during DNA replication and in quiescent cells during maintenance and repair of chromosomes. The findings of an experiment performed indicate that ACF/CHRAC functions in the assembly of periodic nucleosome arrays that contribute to the repression of genetic activity in the eukaryotic nucleus.

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Transcriptional activation triggers deposition and removal of the histone variant H3.3

Article Abstract:

Drosophila HSP70 genes is found to rapidly loses histone H3 and acquires variant H3.3 histones as they are induced. Observations on the HSP70 genes shows that the stability of chromatin-bound H3.3 differs between loci: H3.3 turns over at continually active rDNA genes, but becomes stable at induced HSP70 genes that have shut down.

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The MTE, a new core promoter element for transcription by RNA polymerase II

Article Abstract:

The MTE (motif ten element), a new core promoter element that appears to be conserved from Drosophila to humans is described. The study indicates that the MTE is a downstream core promoter element, which is important for transcription by RNA polymerase II.

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