Ablation of the Retinoblastoma gene family deregulates G(sub.1) control causing immortalization and increased cell turnover under growth-restricting conditions

Article Abstract:

Ablation of the retinoblastoma gene family has been found to deregulate G(sub.1) control. This causes immortalization and greater cell turnover where there are growth-restricting conditions. Triple-knockout mouse embryonic fibroblasts (MEFs) kept anchorage dependence, but lacked proper G(sub.1) control and showed greater cell turnover under in those conditions which limit growth.

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The Rb/E2F pathway: expanding roles and emerging paradigms

Article Abstract:

The retinoblastoma gene encodes a phosphoprotein, Rb, which arrests cells in the G(sub.1) phase and ws the first of tumor-suppressing genes identified. The Rb/E2F pathway and its expanding roles and emerging paradigms are discussed in this review article. Current knowledge of the mechanism of Rb and its roles in apoptosis, cell cycle regulation, and development are reviewed.

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Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130

Article Abstract:

The hypothesis that loss of pRB causes retinoblastoma in humans and pituitary gland tumors in mice and tumorigenesis in other tissues may be suppressed by p107 and p130 is tested by generating chimeric mice from embryonic stem cells carrying compound loss-of-function mutations in the Rb gene family. It is concluded that in a variety of tissues tumor development by loss of pRB is suppressed by its homologs p107 and p130.

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