Article Abstract:
Recent evidence shows that Arm (armadillo gene product) protein, an integral part of Wingless (wg) signaling in Drosophila sp., also acts as an activator of transcription of mutational messages to the nucleus in addition to its role in forming protein-binding complexes needed in building cytoskeletal structures. TCF (T cell factors) protein, a DNA-bound transcriptional activators, interact with Arm protein which in turn, gives access to the terminus that give the same segment polarity phenotype as that of wg. To activate the arm's transcriptional factor, there should be an increase in the cytoplasmic concentration of free Arm molecules in order to bind to TCF.
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Article Abstract:
A study is conducted to demonstrate that the ligand binding pocket of the Drosophila nuclear receptor E75 contains a heme prosthetic group. A correlation between the levels of E75 expression and the levels of available heme suggest a possible role as a heme sensor while the E-75-DHR3 interaction, regulated by the binding of NO or CO to the heme center, suggests that E75 may also function as a diatomic gas sensor.
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Article Abstract:
The fruit fly E75 nuclear receptor contains heme in its ligand binding pocket. Study is conducted on how heme, gas signaling and nuclear receptors interact to control metabolic and developmental pathways.
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