Article Abstract:
Nuclear hormone receptors (NRs) are known to be involved in a diverse set of physiological functions that includes homeostasis, cell differentiation and control of embryonic development. Much attention has been paid to these NRs, so much so that over 300 sequences of NRs have been identified since the late 1980s. However, the plethora of names derived using an outdated nomenclature has made life needlessly difficult for researchers. For this reason, a unified nomenclature system is proposed wherein names are chosen on the basis of a phylogenetic tree that links all known NR sequences.
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Article Abstract:
Mice without hepatocyte nuclear factor 1 (HNF1) die during weaning after a progressive wasting syndrome and enlarged kidneys. The transcription rate of genes such as albumin and alpha-1-antitrypsin is decreased while the gene coding for phenylalanine hydroxylase is totally inactivated, causing phenylketonuria. These mice also have Fanconi syndrome because of the malfunction of the renal proximal tube.
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Article Abstract:
A study was conducted to determine if the heat shock protein Hsp90 or another constituent of Hsp90-containing multichaperone complexes can be considered as major repressors of heat shock transcription factor HSF1. In this study, an in vitro system that recapitulates the initial step of HSF activation in vivo was made. Results confirmed the ability of Hsp90 in functioning as HSF1 repressor.
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