A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(super Kip1)-deficient mice

Article Abstract:

The disruption of the murine p27(super Kip1) gene in mice increases the body size, and causes tumorigenesis and female sterility. An increase in T lymphocyte proliferation causes thymic hyperplasia. The T cells show increased interleukin-2 responsiveness. The lack of p27 increases proliferation of hematopoietic progenitor cells in the spleen. The deletion of both p27 and Rb gene gene causes neoplastic growth of the pituitary pars intermedia. The maturation of the secondary ovarian follicles into corpora lutea is defective in the absence of p27.

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Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration

Article Abstract:

Results show that phosphorylation of the tyrosine kinase FAK by the serine/threonine kinase Cdk5 at serine 732 is required for microtubule formation, nuclear movement, and neuronal migration. Data indicate that overexpression of the nonphosphorylatable FAKs732 mutant causes disorganization of the microtubule fork, nuclear movement disorder, and neuronal positioning defects.

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G protein beta(sub gamma) subunits and AGS3 control spindle orientation and asymmetric cell fate of cerebral cortical progenitors

Article Abstract:

An attempt is made to establish that Gbeta(sub gama) subunits of heterotrimeric G proteins are required for proper mitotic-spindle orientation of neural progenitors in the developing neocortex. Observations indicate that the cell-fate decision of daughter cells is coupled to mitotic-spindle orientation in progenitors.

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