A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex

Article Abstract:

A study was conducted to analyze the isolation and functional synthesis of a new transcriptional activator called steroid receptor RNA activator (SRA). Functional and mechanistic evidence that SRA functions as an RNA transcript were given. Results indicated that SRA exists in ribonucleoprotein complexes. Findings also showed that it may function to confer functional specificity upon multiprotein complexes recruited by liganded receptors.

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The SRC-3/AIB1 Coactivator is degraded in a Ubiquitin- and ATP- Independent manner by the REG(gamma) proteasome

Article Abstract:

Cellular levels of REG(gamma) expression affect estrogen-receptor target-gene expression and cell growth as a result of its ability to promote degradation of the SRC-3 protein. In vitro proteasome proteolysis assays using purified REG(gamma), SRC-3, and the 20S proteasome reinforce these conclusions and demonstrate that REG(gamma) promotes the degradation of SRC-3 in a ubiquitin- and ATP-independent manner.

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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

Article Abstract:

Studies were conducted to highlight the role of the SIN1-rictor-mammalian target of rapamycin (mTOR) complex in defining the function and specificity of Akt. The findings show that the SIN1-rictor-mTOR function in Akt-Ser473 phosphorylation is required for rictor-mTOR function in cell survival but is dispensable for raptor-mTOR function.

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