A splice variant of CD44 expressed in the apical ectodermal ridge presents fibroblast growth factors to limb mesenchyme and is required for limb outgrowth

Article Abstract:

CD44 is a splice variant that seems essential for the growth of limb mesenchymal cells. CD44 carries epitopes that colocalize temporally and spatially with fibroblast growth factor-8 in the apical ectodermal ridge during early limb development. CD44 is probably relevant in physiological and pathological cases where signaling molecules are presented to neighboring cells by cell surface proteins.

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The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44

Article Abstract:

The neurofibromatosis-2 (NF2) tumor suppressor gene product, merlin, has been found to mediate contact inhibition of growth through signals from the extracellular matrix, through interactions with CD44. An inducible promoter was used to drive merlin expression in a rat schwannoma cell line. CD44 and merlin seem to form a molecular witch that specifies cell growth proliferation/arrest.

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Brg1 is required for murine neural stem cell maintenance and gliogenesis

Article Abstract:

The role of Brg1 (brahma-related gene 1) for the sustenance of the neural stem cells and development of glial cells in mouse embryos is studied.

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