Article Abstract:
In vivo footprinting and chromatin-mapping experiments have shown that the single metal response element (MRE) plays a critical role in transcriptional autoactivation by the Amt1 copper metaloregulatory transcription factor in Candida glabrata. Transcription occurs when MRE binds to the Amt1 gene, resulting in protection from toxic levels of copper. The AMT1 promoter region within a nucleosome offers a mechanism for rapid transcription factor access to evoke response to copper.
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Article Abstract:
The role of MeCP2 protein and Sp1 gene in the maintenance of differentiated cells was analyzed via selective gene disruptions in mice during embryogenesis. Targeted disruption of the Sp1 gene in mice impaired normal embryogenesis and induced a broad range of abnormalities due to defective cell differentiation. On the other hand, reduced expression of the MeCP2 gene also impaired the maintenance of differentiated embryonic cells in Sp1 mutants.
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Article Abstract:
The expression of Pitx2 is normally limited to the left lateral plate mesoderm and it is normally found in the structures derived from this embryonic region during organogenesis. It codes for a transcription factor and its expression is modulated by two gene products, Nodal and Sonic hedgehog. The expression of this gene on the right lateral plate mesoderm results to reversal of the location of various organs.
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