Article Abstract:
The effects of rapamycin on translation and on factors such as sub p 70 super S6k and 4EBP1 suggests a signaling pathway emanating from growth factor receptors and leading to translation control. This effect on translation may explain why rapamycin can inhibit G1 cell cycle progression. Other mechanisms that activate the rapamycin-sensitive signaling pathway include cycloheximide and puromycin, which cause in vivo phosphorylation of S6, and anisomycin and cycloheximide treatment, which have been observed to activate sub p 70 super S6k in a rapamycin-sensitive manner and cause 4E-BP1 phosphorylation.
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Article Abstract:
The SKP1 gene in yeast has been identified as a dosage suppressor of a kinetochore protein mutant. Genetic and biochemical analyses show that the gene encodes an intrinsic 22.3 kDa subunit of the multiprotein complex CBF3, which binds centromere DNA in vitro. The subunit, which is a highly conserved protein found in multicellular eukaryotes, is found to be involved in both structural and regulatory functions. It could also serve as a direct link between the kinetochore and the cell cycle machinery.
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Article Abstract:
The Schizosaccharomyces pombe cell cycle depends on the regulation of START, a point in G1 which determines the cell's passage through mitosis. The S. pombe gene corresponding to a new START gene was identified and characterized. Mutation analysis showed that single mutations in sct1 arrests mitosis and derepresses the mating pathway. Further analysis indicates that sct1 is a component of a nutrition monitoring pathway which dictates the fate of cells depending on environmental conditions.
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