A short primer on RNAi: RNA-directed RNA polymerase acts as a key catalyst

Article Abstract:

Research has been conducted on the gene silenced by the RNA interference. The review of the articles on the biochemical and genetic evidence demonstrating that the RNA-directed RNA polymerase chain reaction amplifies interference caused by the trigger dsRNA is presented.

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Mutations in the RNA component of RNase MRP cause a pleiotropic human disease, cartilage-hair hypoplasia

Article Abstract:

Research has been conducted on the cartilage-hair hypoplasia, an inherited developmental disorder with the predesposition to cancer. The results of the several mutations carried in the untranslated RMRP gene which cosegragate with this disorder are described.

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Loading Rho to terminate transcription

Article Abstract:

The author reviews the publications on hexameric RNA/DNA helicase Rho required for transcriptional termination mechanisms in bacteria. The topics of interest include the analysis of organization of individual RNA-binding domains.

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