Article Abstract:
The Vibrio cholera gene int, which encodes a protein related to the integrase family of site-specific recombinases, was identified. It is located to a site comprised of sequences that resemble bacteriophage attachment half-sites. It is apparently most closely related to the Escherichia coli cryptic prophage (CP4-57) integrase protein. Several V. cholerae strains were subjected to genomic analysis, showing that only vibrios that can cause epidemic Asiatic cholera have the TCP-ACF colonization gene cluster in association with the integrase.
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Article Abstract:
The genes encoding the serine-aspartate (SD) repeat-containing proteins SdrC, SdrD and SdrE found in a Staphylococcus aureus strain Newman were examined. Previous studies revealed that the SD repeats were discovered in the S. aureus fibrinogen-clumping factors ClfA and ClfB. The Sdr proteins were distinguished from ClfA and ClfB by the two to five additional 110-113 residue repeated sequences found between region A and R-region. The C-terminal R-domains of the Sdr proteins possessed 132-170 SD residues.
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Article Abstract:
A comparison of the structures of the fnb locus of strain 879R4SSp of Staphylococcus aureus and strain 8325-4 using PCR and Southern hybridization analysis showed that the former has a single fnb gene which is homologous to the fnbA gene. Sequencing of 41 bp of 5' non-coding and 237 bp of 5' coding DNA confirmed this finding. These showed that Tn918 was inserted 41 bp 5' to fnbA in the low-fibronectin-binding mutant 879R4SSp/1536, between the promoter and initiation codon.
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