A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen

Article Abstract:

The role of the BLR1 G protein-coupled receptor in the migration of B and T lymphocytes into splenic follicles was analyzed in mice with mutated blr1 genes. The mutant mice exhibited defective inguinal lymph nodes and Payer's patches including the aberrant formation of primary follicles in the spleen and germinal centers (GC). Furthermore, the B cells of the mutants did not migrate into the splenic follicles due to the absence of functional GC and BLR1.

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CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs

Article Abstract:

The primary immune response, coordinated by CCR7 by establishment of functional microenvironments in secondary lymphoid organs, is discussed. Mice with a disrupted CCR7 locus have been generated to test the function of CCR7, which was shown to be a major homing receptor and regulator for setting up an antigen-specific immune response.

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The leukotriene C(sub)4 Transporter MRP1 regulates CCL 19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes

Article Abstract:

Results demonstrate that migration of dendritic cells from skin to lymph nodes is regulated by multidrug resistance-associated protein 1 (MRP1) through transport of leukotriene C(sub)4 transporter, which influences CCL19 chemotaxis and mobilization of dendritic cells.

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