A plethora of lesion-replicating DNA polymerases

Article Abstract:

Recent findings relating to lesion-replicating DNA polymerases, of which there are many and which are key participants in translesion replication, are discussed. It appears that yeast, bacteria and humans accomplish tranlesion DNA synthesis by a common mechanism and in each case the main replicase for the organism, unable to bypass the lesion, dissociates from the template to leave a 3' primer terminus before the lesion. Then translesion replication is catalyzed by one of the DNA polymerases recently described.

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Ironing out the kinks: splicing and translation in bacteria

Article Abstract:

The RNA substrate has to perform different functions in bacteria splicing and translation as opposed to eukaryotic cells.Splicing requires an elaborate tertiary structure and translation requires comparative freedom from secondary structure. This contradiction is addressed and the results have implications for coupling of eukaryotic pre-mRNA splicing and translation.

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Localization-dependent translation requires a functional interaction between the 5' and 3' ends of oskar mRNA

Article Abstract:

Research to understand the process of derepression of localized mRNA shows the role of a specific elements in the 5' and 3' region of the oskar mRNA. Protein localization accounts for cell development and differentiation. When the mRNA reaches a specific domain it is derepressed and gene translation takes place. The process is discussed.

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