A perfect message: RNA surveillance and nonsense-mediated decay

Article Abstract:

Several studies on yeast and human genetic disorders have led to the discovery of an RNA surveillance mechanism called nonsense-mediated mRNA decay (NMD). Findings from these studies suggested that most of the available evidence can be merged into a common NMD model called the posttermination surveillance model, which characterizes NMD as a control mechanism for perfect messages in eukaryotic cells. However, further studies are required to confirm the feasibility of the model, particularly with regards to mammalian cells.

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Balancing acts: molecular control of mammalian iron metabolism

Article Abstract:

A study of iron biology focusing on physiology and homeostatis to understand how cells and organisms regulate their iron content and orchestrate iron allocation, and how dysregulated iron homeostatis leads to common hematological, metabolic, and neurodegenerative diseases is presented. The fact that this study provides novel insights into gene regulation and links to the immune system is outlined.

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Obesity wars: molecular progress confronts an expanding epidemic

Article Abstract:

The alarming rise in obesity worldwide is reported. The new molecular and physiological insights underlying the regulation of energy balance provide exciting possibilities for successful therapies.

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