A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system

Article Abstract:

Existence of a complex of novel functional nuclear receptor coactivators not known before has been shown. The vitamin D3 receptor ligand-binding domain (VDR LBD) has been used as an affinity matrix to identify parts of a nuclear extract active in transcription. As a response to ligand, the components interact with VDR. At least 10 VDR interacting proteins (DRIPs) from 65 to 250 kD associate in a complex with the receptor in a way that is strictly dependent on 1,25-dihydroxyvitamin D3.

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C/EBP-beta, but not C/EBP-alpha, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland

Article Abstract:

The CCAAT/enhancer binding proteins (C/EBPs) are expressed differentially in mammary gland development. They interact with binding sites in the promoter of beta-casein, a milk protein gene. C/EBP-beta is necessary for lobuloalveolar development, ductal morphogenesis, and functional differentiation of mammary epithelial cells in mice. However, C/EBP-alpha has not been found to play an essential role in these processes.

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Defective trophoblast function in mice with a targeted mutation of Ets2

Article Abstract:

Ets2 is necessary for placental function, for regulating hair development and for mediating growth factor signaling to target genes such as MMP-3 and MMP-9. Mouse embryos deficient in the Ets2 transcription factor die in 8.5 days.Combining mutant embryos with tetraploid mouse embryos provided them the essential extraembryonic tissues.

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