A novel labeling technique reveals a function for histone H2A/H2B dimer tail domains in chromatin assembly in vivo

Article Abstract:

A new technique was used to look at the role of the amino-terminal tails of the H2A/H2B dimer in replication-coupled assembly in live cells. The domains have been found to be unnecessary for nuclear import, but at least one tail is necessary for replication-dependent active assembly of H2A/HwB dimers into chromatin in a living cell.

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Chromatin remodeling and histone modification in the conversion of oligodendrocyte precursors to neural stem cells

Article Abstract:

Conversion of oligodendrocyte precursor cells (OPCs) to neural stem-like cells (NSLCs) is associated with the modification of Lys 4 and Lys 9 of histone H3 to an enhancer in the sox2 promoter. The findings suggest that the conversion of OPCs to NSLCs depends on progressive chromatin remodeling, mediated in part by Brcal1 and Brm.

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Replication-independent core histone dynamics at transcriptionally active loci in vivo

Article Abstract:

A novel labeling technique is used in the naturally synchronous organism Physarum polycephalum to examine the fate of core histones in G2 phase. It was found that transcribed regions of the ribosomal RNA gene loci exhibit rapid exchange of H3/H4 tetramers.

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