A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells

Article Abstract:

A novel form of the AP-1 clathrin adaptor complex is discussed. It mediates basolateral targeting in polarized epithelial cells and contains as a subunit micro1B, an epithelial cell-specific homolog of the widely expressed micro1A. Basolateral sorting is mediated by an epithelial cell-specific version of the AP-1 complex having micro1B in it.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

A novel cellular phenotype for familial hypercholesterolemia due to a defect in polarized targeting of LDL receptor

Article Abstract:

Research shows that the familial hypercholesterolemia receptor mutant is mistargeted to the apical surface of Madin-Darby canine kidney and hepatic epithelial cells, leading to a reduction in LDL endocytosis. Data suggest that expression of a defective polarized LDL receptor in hepatocytes leads to hypercholesterolemia.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

Dendritic cells: specialized and regulated antigen processing machines

Article Abstract:

The purpose of this minireview is to discuss the publication on the dendritic cells. The ability of these cells to capture and process antigens in a distinct manner has been investigated and the results are presented.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code: