A novel checkpoint mechanism regulating the G1/S transition

Article Abstract:

The mechanism of cell cycle delay in the G1 phase of chromatic binding in yeast cells in the S-phase entry is investigated. It was observed that the cell cycle delay functions as a novel checkpoint using a novel mechanism involving the Gen2 kinase, which regulates translation according to the nutrient supply.

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Tid1/Rdh54 promotes dissociation of Dmc1 from nonrecombinogenic sites on meiotic chromatin

Article Abstract:

Tid1/Rdh54, a member of the Swi2/Snf2 family of DNA translocates, has been shown to stimulate Dmc1-dependent recombination. A demonstration that Dmc1 could associate with chromatin in the absence of DNA double-strand breaks (DSBs) and Tid1 suppresses this association is presented.

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Budding yeast Hed1 down-regulates the mitotic recombination machinery when meiotic recombination is impaired

Article Abstract:

A meiosis-specific protein (Hed1) with a novel Rad51 regulatory function is described. It is proposed that Hed1 protein provides a mechanism to ensure the coordinated action of Rad51 and Dmc1 during meiosis, by down-regulating Rad51 activity when Dmc1 is unavailable.

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