Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction

Article Abstract:

A protein involved in membrane trafficking and signal transduction, Hrs, has been investigated. The 2-angstrom X-ray structure of the 219-residue N-terminal VHS and FYVE tandem domains has been determined. The structure made up of the two domains constitutes an exact 2-fold-related homodimer by means of antiparallel association of FYVE domains, in the main.

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A novel all helix fold of the AP180 amino-terminal domain for phosphoinositide binding and clathrin assembly in synaptic vesicle endocytosis

Article Abstract:

Research has been conducted on the clathrin-mediated endocytosis. The role of this endocytosis in retrieving synaptic vehicles from the plasma membrane following exocytosis has been investigated and the results are presented.

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Crystal structure of Pl-Scel, a homing endonuclease with protein splicing activity

Article Abstract:

The crystal structure of the the yeast PI-Scel bifunctional protein was analyzed at 2.4 angstrom resolution to characterize the structure-function relationships of the protein. Analysis of the crystal structure of the yeast PI-Scel indicated the presence of a highly conserved amino acid residue in the nucleolytic active site. The bifunctional yeast protein also exhibited structural-functional duality and acted as a monomeric endonuclease.

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