A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts

Article Abstract:

A study showed that CD2 binding to ligand results to protein segregation, CD2 clustering and T cell polarization. The protein segregation is independent of the cytoplasmic domain of CD2, while the CD2 clustering and cytoskeleton polarization are mediated by binding of the CD2 cytoplasmic domain with a new SH3-containing protein called CD2-associated protein (CD2AP). These indicate that the CD2AP seems to promote receptor patterning and cytoskeletal polarization in the T cell contact area.

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Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells

Article Abstract:

A single-molecule and scanning confocal imaging was used to characterize the behavior of GFP-tagging signaling proteins in Jurkat T cells. Data suggested that diffusional trapping through protein-protein interactions creates microdomains that concentrate or exclude cell surface proteins to facilitate T cell signaling.

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Getting downstream without a Raft

Article Abstract:

The role of plasma-membrane microdomains in the organization of signaling proteins is a controversial issue in T cell signaling. Single-molecule fluorescence is used to suggest that protein-protein interactions, not detergent insolubility, regulate the assembly of signaling complexes in the plasma membrane.

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