A novel CNS gene required for neuronal migration and involved in x-linked subcortical laminar heterotopia and lissencephaly syndrome

Article Abstract:

Research was conducted to investigate the cloning of a central nervous system gene that was highly characterized in developing brain and neuronal cells that encoded for Doublecortin, a 40 kDa predicted protein. Total RNA was determined from lymphoblastoid cell lines using the guanidium thiocyanate method. Results indicated that presence of a transcript at very high fetal brain level. They also suggested the use of at least four genes to function in the transport of neurons during cortical histogenesis.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

A role for the roof plate and its resident TGFbeta-related proteins in neuronal patterning in the dorsal spinal cord

Article Abstract:

Roof plates and TGFbeta-related proteins were studied to determine its function in stimulating and patterning interneurons in the dorsal spinal cord. Results show that two interneurons called D1 and D2 were produced near the roof plate and its production was induced by the the TGFbeta family. Thus, it is derived that neurons are patterned due to the signals induced by the TGFbeta-related proteins in the dorsal spinal cord and later multiplied by the roof plate.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord

Article Abstract:

BMP signaling may be a significant part of assigning neuronal identity within the mammalian central nervous system. GDF7, a BMP family member, was examined for its ability to generate neuronal cell types in the dorsal spinal cord. GDF7 was found to promote differentiation in D1A and D1B neuron classes, so this clearly provides an inductive signal.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code: