A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling

Article Abstract:

The question in development biology regarding how a limited repertoire of growth factors and their receptors act in concert to coordinate the construction of morphologically and functionally complex organs and tissues is addressed. NT-3 and NGF coordinate sympathetic axon growth, innervation of targets, and survival in a manner dependent on the differential control of Trka internalization, trafficking, and retrograde signaling.

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Tangential neuronal migration controls axon guidance: A role for neuregulin-1 in thalamocortical axon navigation

Article Abstract:

The development of the thalamocortical projection, one of the most prominent tracts in the mammalian brain, depends on the early tangential migration of a population of neurons derived from the ventral telecephalon is shown. The results demonstrate that in this process two different products of the Neuregulin-1 gene, CRD-NRG1 and lg-NRG1, mediate the guidance of thalamocortical axons.

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Neuropilin is a Semaphorin III receptor

Article Abstract:

A study was conducted on neuropilin, the type I transmembrane neurodevelopment protein that functions as a receptor of the secreted protein Semaphorin III. Neuropilin-2, a member of the neuropilin family, was also examined. Results indicate that neuropilin and neuropilin-2 may be found in distinct and overlapping populations of rat embryonic nervous system neurons.

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