A mutation in separase causes genome instability and increased susceptibility to epithelial cancer

Article Abstract:

A study demonstrates that a mutation in the mitotic regulator separase is responsible for the cell cycle defect, which is seen in the zebrafish mutant, cease&desist [cds]. Analysis of cds homozygous mutant embryos reveals high levels of polyploidy and aneuploidy, spindle defects and a mitotic exit delay which support a conserved cross-species role for mitotic checkpoint genes in genetic stability and epithelial carcinogenesis.

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Hematopoietic stem cell fate is established by the Notch-Runx pathway

Article Abstract:

The effects of Notch signaling on hematopoietic stem cell (HSC) number during zebrafish development and adulthood, defining a critical pathway for stem cell specification is analyzed. Notch-Runx pathway is defined as critical for the development specification of HSC fate and the subsequent homeostatis of HSC number, thus providing a mechanism for amplifying stem cells in vivo.

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DTL/CDT2 is essential for CDT1 regulation and the early G2/M checkpoint

Article Abstract:

A study reports that DTL is required for the early, radiation induced G2/M checkpoint in both zebrafish and human cells. It is proposed that a CUL4-DDB1-DTL complex ubiquitinates another key cell cycle regulator in G2 as part of the activation of the G2/M checkpoint.

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