A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBP alpha regulates human granulopoiesis

Article Abstract:

MicroRNAs play an important role in animals and plants by controlling translation and stability of specific target mRNAs whereas human granulocytic differentiation is controlled by a regulatory circuitry involving miR-223 and two transcriptional factors, NFI-A and C/EBPalpha. Some microRNAs show ubiquitous express, while others are limited to certain tissues and cell types.

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Homeodomain-mediated [beta]-catenin-dependent switching events dictate cell-lineage determination

Article Abstract:

An unexpected strategy for [beta]-catenin-dependent regulation of cell-lineage determination based on interactions between [beta]-catenin and a specific homeodomain factor, Prop1, is presented. A novel transcriptional strategy that underlies [beta]-catenin control of cell-lineage determination in organogenesis is discovered during the study.

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CAMTA in cardiac hypertrophy

Article Abstract:

Calmodulin binding transcription activator 2 (CAMTA2) is an indispensable transcription coactivator for cardiac hypertrophy. CAMTA2 is activated by the disassociation of class II histone deacetylase 5 and promotes transcription of genes involved in cardiac hypertrophy through its interaction with Nkx2-5

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