A mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans

Article Abstract:

MDT-15, a subunit of the Caenorhabditis elegans Mediator complex, is identified as a Nuclear Hormone Receptor -49-interacting protein and transcriptional coactivator. The C.elegans NMH-49 coordinates expression of fatty acid (FA) metabolic genes during periods of feeding and in response to fasting, and findings imply that a single subunit of MDT-15 integrates the activities of several distinct regulatory factors to coordinate metabolic and hormonal regulation of FA metabolism.

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Defining the transcriptional redundancy of early bodywall muscle development in C. elegans: Evidence for a unified theory of animal muscle development

Article Abstract:

The myogenic potential of each myogenic regulatory factor (MRF), along with two additional Caenorhabditis elegans proteins, UNC-120/SRF and HND-1/HAND, is assayed and characterized to clarify their roles in bodywall muscle development. Caenorhabditis elegans bodywall muscle development is found to be dependent on transcription factors that are associated with all three types of mammalian muscle.

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A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction

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The article describes the regulatory role of protein phosphatase 2A (PP2A) regulatory B subunit in Ras-mediated signal transduction. Genetic analysis showing that sur-6 PP2A-B regulates Ras pathway signaling during vulval induction is presented.

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