Article Abstract:
A major locus for autosomal recessive retinitis pigmentosa (arRP) has been identified on 6q between markers D6S257 and D6S1644. It was established by homozygosity mapping in inbred families of chromosomal regions containing gamma-aminobutyric acid-receptor clusters. RP has extensive allelic and nonallelic genetic herogeneity. It appears that 10-20% of Spanish families affected by typical arRP may have linkage to the new locus. Of the cases of the disease in Spain, 47% present autosomal recessive inheritance.
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Article Abstract:
Inclusion of sex chromosomes in lymphocyte micronuclei of men in an age-dependent way is discussed on the basis of studies using cultured lymphocytes from 10 men in two age groups, 21-19 and 51-55. For the first time it has been possible to assess micronucleation of the Y chromosome and the (active) X chromosome, both in the same cells, through use of an X-chromosome-specific DNA probe simultaneously detecting the Y chromosome.
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Article Abstract:
Tumor necrosis factor (TNF) biology and the major histocompatibility complex in humans are discussed relative to linkage, with the TNF (ital) gene within the MHC gene cluster, that can make interpretation of studies in animal models difficult. TNF seems to have a significant role in promotion of inflammation, likely in a mode identified from TNF (ital) gene-targeted mice.
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