A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes
Article Abstract:
A multitiered, case-control association study of psoriasis is performed in three independent sample sets of white North American individuals which provides statistical support for two psoriasis-susceptibility loci one in Sq31.1-q33.1 and the other in 1p31.3. Preliminary analyses suggest that the combination of risk and protective haplotypes at both loci can lead to a more than threefold differential risk for disease.
author: Cargill, Michele, Krueger, Gerald G., White, Thomas J., Begovich, Ann B., Prescott, Stephen M., Leppert, Mark F., Civello, Daniel, Hansen, Christopher B., Callis, Kristina P., Papenfuss, Jason, Ardlie, Kristin G., Schrodi, Steven J., Chang, Monica, Gracia, Veronica E., Brandom, Rhonda, Matsunami, Nori, Catanese, Joseph J., Leong, Diane U., Panko, Jackie M., McAllister, Linda B.
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
Risk factors, Psoriasis, Quantitative trait loci
Familial eosinophilia maps to the cytokine gene cluster on human chromosomal region 5q31-q33
Article Abstract:
The autosomal dominant disorder familial eosinophilia has been mapped through research to the cytokine gene cluster. Using 312 separate polymorphic markers in a genomewide search, scientists found links for the disorder within the cytokine gene cluster. These were then subjected to resequencing. Results have ruled out mutation, but further research is needed to determine causation.
author: Cargill, Michele, Tucker, Margaret A., Goldstein, Alisa M., Lin, Albert Y., Zimmerman, Peter A., Lander, Eric, Rioux, John D., Daly, Mark J., Green, Todd, Nutman, Thomas, Stone, Valerie A., Nguyen, Huy, Hudson, Thomas
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
Genetic disorders, Cytokines, Eosinophilia, Human chromosome abnormalities
Neuropathy target esterase gene mutations cause motor neuron disease
Article Abstract:
Several genome-wide analyses are conducted to explain the connection of the organophosphorus (OP) compounds with the motor neuron disease (MND). The MND is caused by the neuropathy target esterase (NTE) that is usually inhibited by the OP compounds.
author: Leppert, Mark, Rainier, Shirley, Matsunami, Nori, Coon, Hilary, Bui, Melanie, Mark, Erin, Thomas, Donald, Tokarz, Debra, Lei Ming, Delaney, Colin, Richardson, Rudy J., Albers, James W., Stevens, Jeff, Fink, John K.
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2008
All Other Basic Organic Chemical Manufacturing, Industrial Organic Chemicals, Organophosphates, Organophosphorous Compounds, Gene mutations, Gene mutation, Esterases, Motor neuron disease, Organophosphorus compounds, Organic phosphorus compounds
subjects list: Health aspects, Research, United States, Genetic aspects, Causes of
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