A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube

Article Abstract:

Progenitor cell identity and neuronal fate in the ventral neural tube are discussed relative to a homeodomain protein code. A group of homeodomain transcription factors expressed by neural progenitors function as intermediaries in Sonic Hedgehog (Shh) -dependent neural patterning.

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Ventral neural patterning by Nkx homeoNkx6.1 controls somatic motor neuron and ventral interneuron fates

Article Abstract:

Ventral neural patterning by Nkx homeoNkx6.1 has been found to control somatic motor neuron and ventral interneuron fates. Patterns of neurogenesis in mice having a targeted mutation were studied. The mutants have a dorsal-to-ventral switch in identity of progenitors and fate of postmitotic neurons.

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A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventrals spinal cord

Article Abstract:

A study was conducted to determine the physiological function of interneuron generation's sonic hedgehog (Shh)-independent, retinoid-activated pathway. Analyses of neurons, Evx1/2 (VO) and En1 (V1), and the ventral progenitors that express the Dbx homeodomain proteins show that Shh signalling in the ventral spinal cord increases the number of of Dbx cells and V0 and V1 formed. However, it is not essential to their initial generation.

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