Article Abstract:
The immunogenic Mycobacterium kansasii lipoprotein, MK35, is an immunogenic antigen. The amino acid sequence of MK35 resembles that of other knownmycobacterial lipoproteins and possesses a consensus prokaryotic motif for lipidation. MK35 demonstrates abnormal electrophoretic mobility and induces delayed-type hypersensitivity reactions in sensitized guinea pigs. The study could help in the development of mycobacterial vaccines and diagnostic reagents.
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Article Abstract:
The A subunit of DNA gyrase in mycobacteria is usually exposed to splicing events as its gene, gyrA, has an insertion encoding an intein. Studies on several kinds of isolates of Mycobacterium kansasii, Mycobacterium malmoense, Mycobacterium marinum, Mycobacterium ulcerans and Mycobacterium xenopi showed that the presence of GyrA inteins is not by chance but a taxonomic character specific for a given taxon at a species or subspecies level.
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Article Abstract:
Specific labelling, haemagglutination and porphyrin assays on cloned Vibrio cholerae 01 genes were employed to identify the first bacterial member of the alpha2-microglobulin lipocalin, VlpA genes. Results have shown that VlpA is an outer-membrane protein exhibiting a lipoprotein characteristic. Furthermore, the activity of VlpA as a haemin-building protein indicated a possible involvement in iron uptake.
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