A heterologous reductase affects the redox balance of recombinant Saccharomyces cerevisiae

Article Abstract:

The influence of xylose reduction on product formation by anoxic glucose metabolism in xylose reductase (XR) expressing Saccharomyces cerevisiae is investigated using chemostat culture. Two different dilution rates are used, with a transition experiment being performed at each rate. Results indicate that the conversion of xylose to xylitol by a heterologous XR in S. cerevisiae significantly affects the redox balance of the cell. Some of these effects remain even after a second enzyme, XDH, is introduced into the cell.

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Replicative ageing and senescence in Saccharomyces cerevisiae and the impact on brewing fermentations

Article Abstract:

Saccharomyces cerevisiae and the impact on brewing fermentation of its replicative aging and senescence are discussed in this review article. Topics include the yeast cell cycle, mitochondrial DNA damage and aging, and phenotypic characteristics associated with aging and senescence.

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Adr1 and Cat8 synergistically activate the glucose-regulated alcohol dehydrogenase gene ADH2 of the yeast Saccharomyces cerevisiae

Article Abstract:

Results demonstrate that derepression of the glucose-repressible alcohol dehydrogenase II is mediated by the regulators Adr1 and Cat8, which synergistically interact/bind with UAS1 and UAS2, respectively. The UAS2 is a variant of the carbon source-responsive element.

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