A genomewide single-nucleotide-polymorphism panel for Mexican American admixture mapping
Article Abstract:
An admixture study in Mexican Americans (MAM) was conducted by defining genomewide single-nucleotide-polymorphism (SNP) panel that can distinguish between chromosomal segments of Amerindian (AMI) or European (EUR) ancestry. It is shown that using realistic simulation parameters this panel of SNP ancestry-informative markers provides good power for detecting disease-associated chromosomal segments for genes with modest ethnicity risk ratios.
author: Gregersen, Peter K., Knowler, William C., Belmont, John W., Chao Tian, Hinds, David A., Shigeta, Russell, Ballinger, Dennis G., Seldin, Michael F., Adler, Sharon G., Lee, Annette, Pahl, Madeleine V., Silva, Gabriel, Hanson, Robert L.
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
Chromosome mapping, Mexican Americans, Report
An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians
Article Abstract:
Various research methods have been used to identify genetic loci for type II diabetes mellitus occurring in Pima Native Americans. These included variance-components methodology, and multipoint, bivariate linkage and sib-pair analyses, and were adjusted for age and body-mass index. Results indicate potential loci on chromosomes 1q and 7q for diabetes susceptibility.
author: Timberlake, David, Foroud, Tatiana, Pettitt, David J., Knowler, William C., Bennett, Peter H., Blangero, John, Ehm, Margaret G., Hanson, Robert L., Prochazka, Michal, Thompson, D. Bruce, Kobes, Sayuko, Baier, Leslie, Burns, Daniel K., Almasy, Laura, Garvey, W. Timothy
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
United States, Health aspects, Diabetes, Native Americans, Native North Americans, Body size, Body weights and measures, Genetic disorders, Diabetes research
A genomewide association study of skin pigmentation in a south Asian population
Article Abstract:
Single-nucleotide polymorphisms are used in multistage genomewide association study to systematically investigate genetic factors influencing skin-pigmentation variation among South Asian population. Three genes accounting for skin-pigmentation variation are detected.
author: Jarman, Carl, Cox, David R., Hinds, David A., Stokowski, Renee P., Pant, Krishna P.V., Dadd, Tony, Fereday, Amelia, Filsell, Wendy, Ginger, Rebecca S., Green, Martin R., Ouderaa, van der, Frans J.
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
Pigmentation disorders, Human genome
subjects list: Research, Genetic aspects, Single nucleotide polymorphisms
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