A functional genomic strategy reveals clockwork orange as a transcriptional regulator in the Drosophila circadian clock

Article Abstract:

The identification of a novel clock gene clockwork orange (cwo), a transcriptional repressor in Drosophila is described. It is proposed that the competition between cyclic CLK-CYC activity and the adjustable threshold imposed by cwo keeps E-box mediated transcription within the controllable range of its activity which renders a Drosophila circadian clock capable of generating high-amplitude oscillation.

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Polycomb mediates Myc autorepression and its transcriptional control of many loci in Drosophila

Article Abstract:

The control of myc in Drosophila is examined and it is shown that the Drosophila ortholog, dmyc, undergoes autorepression. The result suggests that the developmental repressor Polycomb (Pc) is required for dmyc autorepression, and this Pc-dMyc-mediated repression spreads across an 875-kb region encompassing the dmyc gene.

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Drosophila lacking microRNA miR-278 are defective in energy homeostasis

Article Abstract:

Evidence to show that the microRNA miR-278 plays a role in the control of energy homeostasis in Drosophila is presented. miR-278 acts by a different mechanism, at least partly through regulation of expanded transcript to control insulin sensitivity in adipose and peripheral tissues.

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