Article Abstract:
A forkhead gene, FoxE3, has been shown to be necessary for closure of the lens vesicle and lens epithelial proliferation in eye development. The cloning of this gene, expressed in the lens epithelium, has been carried out. It is mutated in a classic mouse model with ensuing defective lens development. In the mouse mutant dysgenetic lens (dyl) the lens vesicle does not separate from the ectoderm and fusion between lens and cornea results. With no proliferating anterior lens epithelium absence of secondary lens fibers and a dysplastic cataractic lens results.
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Article Abstract:
Disruption of the Mf1 gene which codes for a forkhead/winged helix transcription factor results in skeletal abnormalities, eye defects and hydrocephalus. This gene is expressed in mesenchymal tissues destined to be cartilages, meninges, periocular tissues, endothelium or kidney. Homozygous null mutation of this gene in mice results in hydrocephalic fetuses containing eye defects. These mice die at birth.
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Article Abstract:
Axenfeld-Rieger anomaly, one of several related autosomal dominant disorders that lead to glaucoma produced by mutations in the forkhead/winged-helix gene, FKHL7 (ital), are discussed. These mutations create anterior-segment defects and glaucoma in some patients, but likely one more locus involved in eye development regulation is at 6p25.
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