Article Abstract:
A developmental transition in definitive erythropoiesis has been studied with the finding that erythropoietin (Epo) expression is regulated sequentially by HNF4 and retinoic acid receptors. The Epo gene enhancer contains a DR2 sequence that represents a retinoic acid receptor-binding site and a retinoic acid receptor transcriptional response element. The transition may switch regulation of Epo expression from retinoic acid control to hypoxic control. The Epo gene is shown to be retinoic acid inducible in embryos.
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Article Abstract:
The lac operator-repressor system has been found to be functional in mice by transferring an entirely functional lac system to mice. The lac system brings the time dimension of mammalian gene expression in animals under reliable, predictable experimental control. It is likely possible to put mutations, even letahl ones, into the mouse genome and to study them at the organismal level.
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Article Abstract:
Functional inactivation of the IGF-I and insulin receptors (IGF-IR and IR) in striated muscle has been found to cause type 2 diabetes. A transgenic mouse with a dominant-negative insulin-like growth factor-1 receptor specifically targeted to the striated muscle was developed for study. The mice, MKR mice, were excellent as a model for this type of study. They showed striking loss of function of the IR and the IGF-IR
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