A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Mat(alpha)2 repressor degradation

Article Abstract:

Research has been conducted on the ubiquitin-proteasome system's substrate discrimination caused by the ubiquitin-protein ligase and ubiquitin-conjugating enzyme combinations. The identification of Doa10/Ssm4 as a yeast E3 embedded in the endoplasmic reticulum/nuclear envelope has been carried out and the results indicate that Doa10/Ssm4 can target soluble transcription factor Mat(alpha)2.

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Trancriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8

Article Abstract:

Research has been conducted on histone H2B. The authors present the evidence for histone's ubiquitylation and deubiquitylation during gene activation, and identify H2B deubiquitylating enzyme in the Spt-Ada-Gcn5-Acetyltransferase complex.

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The RAG 1 N-terminal domain is an E3 ubiquitin ligase

Article Abstract:

Research has been conducted on N-terminal domain of RAG 1. Results demonstrate that this domain has a specific enzymatic role which is different from the rest of the protein.

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