Article Abstract:
Comprehensive linkage analysis of chromosome 21q22 gives support to evidence already assembled for a putative bipolar affective disorder locus. Evidence of linkage to bipolar affective disorder (BP) in one large many-generation family had already been shown to have a LOD score of 3.41 at the PFKL locus on chromosome 21q22.3. There was little support in the study for linkage to PFKL under homogeneity or heterogeneity in other families. Results of a recent expanded analysis with 31 microsatellite markers in the largest multigenerational BP pedigree series so far done have been analyzed. Results of a polylocus analysis were consistent with results that showed a 2-point heterogeneity LOD score of 3.35 at the D21S1260 locus 5 cM proximal to PFKL.
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Article Abstract:
No evidence has been found for significant linkage between bipolar affective (BP) disorder and chromosome 18 pericentromeric markers in a series of multiplex extended pedigrees. BP is a major neuropsychiatric disorder, high in heritability and having complex inheritance. Evidence for significant parent-of-origin effect was not found. Evidence from one of the largest samples so far reported, with 1,013 genotyped persons in 53 unilineal multiplex pedigrees, has been reexamined using 10 highly polymorphic markers and a range of nonparametric and parametric analyses.
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Article Abstract:
Research using association and linkage analysis has provided evidence for a specific locus in occurrences of functional psychoses. Studies of German and Israeli subjects with schizophrenia involved multipoint analysis under assumed heterogeneity, and revealed a linkage to the marker on chromosome 18p. This finding was consistent whether the definition of the affected phenotype was broad or narrow.
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