Article Abstract:
Research was conducted to examine the validity of the hypothesis that a competitive microflora increases the resistance of Salmonella typhimurium to inimical processes such as freeze injury. An spvRA::luxCDDABE reporter was utilized to evaluate RpoS activity in S typhimurium challenged with varying concentrations of a competitive flora. Results suggest a suicide hypothesis for the destruction of rapidly growing cells by inimical processes which lead to the growth arrest of exponential-phase cells and to the decoupling of anabolic and catabolic metabolism.
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Article Abstract:
Efforts to culture cells derived from environmental sources or from cold-stored or starved lab microcosms such as 'Vibrio vulnificus,' 'Micrococcus luteaus,' and 'Escherichia coli' may fail as explained by the concept of cell suicide. This principle states that a metabolic imbalance is created whenever cells are suddenly transferred to nutrient-rich agar under conditions suitable for enzyme activity. As a result, free radicals and superoxide are immediately produced.
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Article Abstract:
The rpoS gene of Salmonella enterica can vary significantly among subspecies, with most changes occurring at the center and near the end of the coding region. This gene produces a sigma factor that permits the bacterium to adapt to stress.
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