A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis

Article Abstract:

A comprehensive analysis of genetic variance in the G-protein-coupled receptor 74 (GPR74) gene using a large cohort of Swedish subjects was carried out. It was found that the ATAG haplotype was associated with increased adipocyte lipid mobilization in vivo and in vitro suggesting that a common haplotype in the GPR74 gene protects against obesity which is caused by a relief of inhibition of lipid mobilization from adipose tissue.

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ELMOD2 is a candidate gene for familial idiopathic pulmonary fibrosis

Article Abstract:

A genomewide scan in six multiplex families with familal idiopathic pulmonary fibrosis (IPF) is performed originating from southeastern finland. The majority of the Finnish multiplex families are clustered in the region, and the population history suggested that the clustering might be explained by an ancestor shared among the patients.

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Genetic background of congenital chloride diarrhea in high-incidence populations: Finland, Poland, and Saudi Arabia and Kuwait

Article Abstract:

Eight new mutations were found in a study of congenital chloride diarrhea (CLD) among populations in Finland, Poland, Saudi Arabia and Kuwait, bringing the total of known CLD gene mutations to 19. Mutations affect the same locus in all cases studied. Evidence of a major founder effect was seen in the Arab patients.

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