A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer

Article Abstract:

A demonstration that the estradiol (E2) stimulation of CCND1 expression in BCC depends on a novel cell-type-specific enhancer downstream from the CCND1 coding region, which is the primary ERalpha recruitment site in estrogen-responsive cells is presented. The results reveal an estrogen-regulated combinatorial network including cell-specific cis- and trans-regulators of CCND1 expression where ERalpha collaborates with other transcription factors associated with the ER-positive breast cancer phenotype, including FoxA1 and NFIC.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

Hedgehog signaling and the retina: Insights into the mechanisms controlling the proliferative properties of neural precursors

Article Abstract:

A novel role for Hedgehog signaling in speeding up the cell cycle in the developing retina by reducing the length of G1 and G2 phases is described. These fast cycling cells tend to exit the cell cycle early and retinal progenitors with blocked Hedgehog signaling cycle more slowly, with longer G1 ad G2 phases and remain in the cell cycle longer which indicates that Hedgehog might play a role in regulating the conversion from slow cycling 'stem' cell to a faster cycling 'transit amplifying' progenitor cell.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

N-cofilin is associate with neuronal migration disorders and cell cycle control in the cerebral cortex

Article Abstract:

The paper examines the cell cycle control of N-cofilin in the cerebral cortex and its role in neurol migration disorders.The mutations affecting regulators contribute to cortex development.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code: