Article Abstract:
In Caenorhabditis elegans an insulin receptor-like signaling pathway regulates development, metaboism, and longevity. A null mutation in the daf-16 (ital) Fork head transcription factor cuts down the requirement for signaling through the pathway. A loss-of-function mutation in pdk-1 (ital), the C. elegans homolog of the Akt/PKB kinase PDK1 in mammals, brings on constitutive arrest at the dauer stage and greater lifespan. The phenotypes are suppressed by loss of function mutation in daf-16 (ital). It has been shown that pdk-1(ital) acitivty is necessary and sufficient to bring on AGE-1PI3K signals in the DAF-2 insulin receptor-like signaling pathway.
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Article Abstract:
Experimental studies enable the identification and characterization of 95 new mutations generating a Dyf phenotype of Caenorhabditis elegans. These mutations inhibit the dye filling of amphid and phasmid neurons, while exert little influence on fertility, mobility and viability. Chemosensory responses are affected by all mutations. 20 mutations are alleles of 13 new genes, namely dyf-1 to dyf-13, and the rest of the mutations are alleles of 12 previously defined genes. The dyf genes play a vital role in the differentiation of amphid and phasmid chemosensilla.
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Article Abstract:
In Caenorhabditis elegans, the daf-12 gene has been found to encode a nuclear receptor that regulates the dauer diapause and developmental age. The gene acts at the convergence of pathways regulating these things. DAF-12 likely integrates hormonal signals in cellular targets to coordinate traits that are important in life history.
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