A DNA integrity network in the yeast Saccharomyces cerevisiae

Article Abstract:

A network governing DNA integrity was identified in yeast by a global genetic analysis of synthetic fitness or lethality defect (SFL) interactions. Modules or genes involved in DNA replication, DNA replication, DNA-replication checkpoint (DRC) signaling, and oxidative stress response were identified as the major guardians against lethal spontaneous DNA damage, efficient repair of which requires the function of the DNA-damage checkpoint signaling and multiple DNA-repair pathways.

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Genetic and epigenetic regulation of the FLO gene family generates cell-surface variation in yeast.

Article Abstract:

The FLO gene family of saccharomyces cerevisiae includes an expressed gene, FLO11 and a set of silent, telomere-adjacent FLO genes. Genetic and epigenetic variations explain the observed heterogeneity of cell-surface protein expression within a population of cells derived from a single clone.

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Global analysis of protein palmitoylation in yeast

Article Abstract:

A new proteomic methodology is used that purifies and identifies palmitoylated proteins to characterize the palmitoyl proteome of the yeast Saccharomyces cerevisiae. This approach identifies 12 of the 15 known palmitoyl proteins plus many new palmitoyl proteins.

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